MU vs Southampton score prediction: Advantage leans towards Old Trafford
At 3:00 a.m. on January 17, MU will host Southampton at Old Trafford in the Premier League.

Both teams are facing many difficulties, but the difference in class and current form makes Man United rated higher than Southampton in this confrontation.
Force situation
Manchester United have been hit hard by the absence of key players. Luke Shaw, Mason Mount, Victor Lindelof and Jonny Evans are all sidelined with injuries. However, the return of Altay Bayindir after his excellent performance in the FA Cup will be a boost for the home team.
Southampton are no better off with Jack Stephens, Juan Larios and Ross Stewart all missing. However, a group of young players such as Tyler Dibling and Kamaldeen Sulemana are bringing positive performance, helping Southampton overcome Swansea City in the FA Cup.
Current form
Manchester United are struggling to stay out of the danger zone in the Premier League table. With just one win in their last seven games, Ruben Amorim’s squad are in need of positive results to regain their form.
Southampton, on the other hand, are having their worst season in Premier League history, sitting bottom with just six points from 20 games. However, a 3-0 win over Swansea City in the FA Cup has given some momentum to Ivan Juric's men.

MU vs Southampton score prediction
With encouraging form and playing at home at Old Trafford, Manchester United, if they maintain high concentration, will be the winning team.
Score prediction: Manchester United 3-1 Southampton.
Despite facing many difficulties, Manchester United are still rated higher than Southampton. The match will be a good opportunity for the Red Devils to regain their form and improve their position on the rankings. If they make good use of the opportunities, coach Ruben Amorim's team can continue to maintain their impressive streak against Southampton at Old Trafford.