MU vs Southampton score prediction: Advantage leans towards Old Trafford
At 3:00 a.m. on January 17, MU will host Southampton at Old Trafford in the Premier League.

Both teams are facing many difficulties, but the difference in class and current form makes Man United rated higher than Southampton in this confrontation.
Force situation
Manchester United have a number of problems with several key players missing. Luke Shaw, Mason Mount, Victor Lindelof and Jonny Evans are all still out injured. However, the return of Altay Bayindir after an excellent performance in the FA Cup will be a support for the home team.
Southampton are no better off with Jack Stephens, Juan Larios and Ross Stewart all missing. However, a group of youngsters such as Tyler Dibling and Kamaldeen Sulemana are bringing positive results, helping Southampton overcome Swansea City in the FA Cup.
Current form
Manchester United are struggling to stay out of the danger zone in the Premier League table. With just one win in their last seven games, Ruben Amorim's squad are in need of positive results to regain their form.
Southampton, on the other hand, are having their worst season in Premier League history, sitting bottom of the table with just six points from 20 games. However, a 3-0 win over Swansea City in the FA Cup has given some momentum to Ivan Juric's men.

Predict the score of MU vs Southampton
With encouraging form and playing at home at Old Trafford, Manchester United, if they maintain high concentration, will be the winning team.
Score prediction: Manchester United 3-1 Southampton.
Despite facing many difficulties, Manchester United are still rated higher than Southampton. The match will be a good opportunity for the Red Devils to regain their form and improve their position in the rankings. If they make good use of the opportunities, coach Ruben Amorim's team can continue to maintain their impressive streak against Southampton at Old Trafford.