Japan discovers substance that regulates cancer metastasis rate

According to Sankei news network on June 21, a group of scientists from the Faculty of Medicine - Keio University in Japan recently discovered an enzyme that plays an important role in regulating the metastasis of cancer cells in the body.

The research team led by Professor Okada Yasunori said that when inhibiting the activity of an enzyme called ADAM28, it immediately reduced the rate of metastasis of cancer cells. Normally, most cells that enter the blood will die, but a portion of them will survive and metastasize to other internal organs in the body.

Prostate cancer cells. (Source: images.google.com)

Professor Yasunori's team has identified a mechanism by which the enzyme ADAM28 - a substance that is highly active in breast and lung cancer cells - neutralizes a molecule called VWF in the blood, thereby allowing cancer cells to escape the pursuit of this molecule and survive.

Scientists injected lung cancer cells that had been deactivated with the above enzyme using gene therapy into experimental mice and compared them with normal lung cancer cells. They found that the movement of cells to the lungs was inhibited to 1/6.

Meanwhile, when breast cancer cells that had disabled the ADAM28 enzyme were injected into mice, metastasis to the liver, lungs, kidneys and brain was inhibited to 1/5./.

According to Vietnam+M