iPS cells do not cause rejection in laboratory mice
According to an article published on the website of the British scientific journal Nature, Japanese scientists found no rejection reaction in laboratory mice after transplanting adult cells produced from induced pluripotent stem cells (iPS).
This new discovery by a group of scientists from the National Institute of Radiological Sciences (NIRS) and Tsurumi University (Japan) challenged the scientific research results in an article published in Nature magazine in 2011 by a group of scientists from the University of California, claiming that iPS cells cause immune responses in mice.
Illustration photo.
The prevailing view among regenerative medicine experts today is that immune reactions do not occur in patients who receive transplants of fully differentiated cells from iPS cells, which are made from the patient's own cells.
The previous report by US scientists on the phenomenon of iPS cell immunity attracted public attention because it went against the conventional view of the scientific community. Those who opposed the discovery questioned why the US research team chose to transplant cells that were not yet fully differentiated - a method that would not be used in medical applications.
In the new paper, NIRS researcher Ryoko Araki and her colleagues created bone and marrow cells from mouse iPS cells and transplanted them into other mice that shared the same genetic traits.
Organ and tissue transplantation is now common in modern medicine. However, rejection of the transplanted tissue is the biggest cause of organ and tissue transplant failure. With the immune system alert, the body sees the foreign organ as an “enemy” and turns to attack the “foreign” tissue that has just been transplanted.
To control this process, patients need to take anti-rejection drugs, but this treatment also causes many harmful side effects on the patient's body. The new discovery about iPS and the practical applications of this pluripotent cell technology in the medical field have truly opened a new direction for world medicine./.
According to (Vietnam+) - VT
